Up-regulation of microsomal prostaglandin E synthase-1 in COX-1 and COX-2 knock-out mouse fibroblast cell lines
✍ Scribed by Duanpen Sandee; Sasitorn Sivanuntakorn; Vanicha Vichai; Jarin Kramyu; Kanyawim Kirtikara
- Book ID
- 113865114
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 450 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0090-6980
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
B/macrophage cells are biphenotypic leukocytes of unknown function that simultaneously express B lymphocyte (IgM, IgD, B220, CD5) and macrophage (phagocytosis, F4/80, Mac-1) characteristics. B/macrophage cells can be generated from purified mouse B lymphocytes incubated in fibroblast-conditioned med
## Abstract Prostaglandin E~2~ (PGE~2~) is among the most important mediators involved in neuroinflammatory processes. The final step of its synthesis is regulated by enzymes termed prostaglandin E~2~ synthases (PGES). Three PGES are known, cytosolic (c)PGES, membrane‐associated (m)PGES‐1 and mPGES
## Abstract ## Objective Microsomal prostaglandin E synthase 1 (mPGES‐1) is the final enzyme of the cascade that produces prostaglandin E~2~ (PGE~2~), a key actor in arthritis. To study mPGES‐1 synthesis in human cartilage and its regulation by interleukin‐1β (IL‐1β), we used human cartilage and a