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230 VALPROIC ACID SUPPRESSES INTERLEUKIN-1β-INDUCED MICROSOMAL PROSTAGLANDIN E2 SYNTHASE-1 EXPRESSION IN CHONDROCYTES

✍ Scribed by N. Zayed; F. El Mansouri; N. Chabane; J. Martel-pelletier; J.-P. Pelletier; H. Fahmi


Book ID
114352011
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
101 KB
Volume
18
Category
Article
ISSN
1063-4584

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## Abstract ## Objective Membrane‐associated prostaglandin E synthase (mPGES) is a recently identified terminal enzyme of the arachidonic acid cascade, which converts PGH~2~ to PGE~2~ in rheumatoid arthritis synovial fibroblasts (RASFs). This study was undertaken to investigate factors regulating