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Histone deacetylase inhibitors suppress interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes

✍ Scribed by N. Chabane; N. Zayed; H. Afif; L. Mfuna-Endam; M. Benderdour; C. Boileau; J. Martel-Pelletier; J.-P. Pelletier; N. Duval; H. Fahmi

Book ID: 118475708
Publisher: Elsevier Science
Year: 2008
Tongue: English
Weight: 578 KB
Volume: 16
Category: Article
ISSN: 1063-4584
DOI: 10.1016/j.joca.2008.03.009

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## Abstract ## Objective To investigate the effects of prostaglandin D~2~ (PGD~2~) on interleukin‐1β (IL‐1β)–induced matrix metalloproteinase 1 (MMP‐1) and MMP‐13 expression in human chondrocytes and the signaling pathways involved in these effects. ## Methods Chondrocytes were stimulated with I