## Abstract N‐[4‐]2‐(5‐Chloro ‐2‐methoxybenzamido) ethyl phenylsulfonyl N′ ‐cyclohexylurea, IXc, or glyburide, has been labeled with tritium and carbon‐ 14. The tritium label is located in the C‐3 position of the 5‐chloro ‐2‐methoxybenzoyl portion of the molecule, while the carbon‐14 label is incor
Microdosimetry of tritium and carbon-14 in different materials
✍ Scribed by Turan Ünak; Saim Selvi
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 146 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0969-8043
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✦ Synopsis
lnlroduclion: The physical, chemical and biological consequences of the interactlou of nuclear radiations with matter is closely depended on the energy deposition in the microscopic scah; of matter by the interacting radiation. In the case of radiations, which have short ranges in the matter, Ihe nlicrodosimetric considerations become very important for interpretation of the radiolytic effects produced in the microscopic scale of matter.
In this context, the energy deposition in diflbrent absorbing media by low-energy beta-rays of 31-1 or 14C requires the microdosimetric considerations. Nevertheless, either experimentally measurement or theoretically calculation of the ranges or stopping powers of low-energy electrons is still problematic. Especially, the calculated stopping powers of lower energy electrons than 500 eV given in the literature are very dispersive depending on the calculation methods applied. On the other hand, the energy deposition calculations were generally applied to the absorption of monoenergetic low-energy electrons or electrons which have a discontinues low-energy spectrum; but, it is not possible to find any study in the literature on the microdosimetry of low-energy beta-rays of 3H and 14C having continous electron energy spectra.
In this study, the energy deposition in teflon and water by the absorption of beta-rays emitted from 3H and 14C have been calculated in the microscopic scale of the absorbing media.
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Timefurone (I), a methyl thioether analogue of khel lin (2), was labeled with tritium at the C-2 position and with carbon-14 at the C-5 position for conducting in uivo biotransformation studies with I . Tritium labeled I was prepared by lithiating and tritiating a silyllated derivative of khellinone
## Abstract Tritium labelled pentamidine has been prepared with a specific activity of 90 mCi mmol^−1^ using a one‐step exchange reaction between the unlabelled drug and tritiated water. The labelling utilised a homogeneous rhodium trichloride catalyst and yielded pentamidine regiospecifically labe