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Microchemical synthesis of the serotonin receptor ligand, 125I-LSD

✍ Scribed by P.R. Hartig; A.M. Krohn; S.A. Hirschman

Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
491 KB
Volume
144
Category
Article
ISSN
0003-2697

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✦ Synopsis

The synthesis and properties of 2-['251]-lysergic acid diethylamide, the first '2sI-labeled serotonin receptor l&and, are described. A novel microsynthesis apparatus was developed for this synthesis. The apparatus employs a micromanipulator and glass micro tools to handle microliter to nanoliter volumes on a microscope stage. This apparatus should be generally useful for the synthesis of radiohgands and other compounds when limited amounts of material must be handled in small volumes. 0 196s Academic PES, IX.

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