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The synthesis of the αvβ3 integrin receptor ligand [125I]L-775,219

✍ Scribed by Terence G. Hamill; Mark E. Duggan; Jim J. Perkins

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
802 KB
Volume
44
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

The α~v~β~3~ integrin receptor ligand [^125^I]L‐775,219, 1c, was synthesized for use in an in vitro receptor binding assay with high specific activity (>1500 Ci/mmol) and a radiochemical yield of 15–20%. Conversion of iodide 1b to the corresponding aryl trimethylstannane 2, followed by radioiodination using Na^125^I/iodobead gave 1c. Copyright © 2001 John Wiley & Sons, Ltd.

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