This paper describes the synthesis of 9-amino-2- and 4-hydroxy- and 2,4-dihydroxy-1,2,3,4-tetrahydroacridines 2 and of 9 -aminomethyl-1,2,3,4-tetrahydro- and 1,2,3,4,5,6,7,8-octahydroacridines 3 starting from the corresponding 9-carboxamido derivatives. A new synthetical pathway to 9-amino-2-hydroxy
Microbiological transformations of 9-amino-1,2,3,4,5,6,7,8-octahydroacridine
โ Scribed by N. A. Parshikov; P. B. Terent'ev; L. B. Modyanova; M. R. Duduchava; E. V. Dovgilevich; K. A. Butakov
- Publisher
- Springer US
- Year
- 1994
- Tongue
- English
- Weight
- 136 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0009-3122
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## Abstract A series of novel 10โaminoโ9โarylโ2,3,4,5,6,7,9,10โoctahydroacridineโ1,8โdione derivatives **4** were synthesized by hydrazine or phenylhydrazine and 9โarylโ1,8โdioxoโ2,3,4,5,6,7,9โheptahydroxanthene derivatives **3**, which were prepared by 5โsubstitutedโ1,3โcyclohexanedione **1** and
In order to prepare new tacrine-like compounds, the title compounds (VII), (X) and (XV) are synthesized. The synthetic pathway to (VII) represents a shorter and more suitable approach to prepare tacrine metabolites. An alternative route from (VIb) to compound (VIII), which exhibits very strong DNA b