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Microbiological transformation of progesterone by some zoosporic fungi

✍ Scribed by A. M. Khallil; Dr. M. Eman Mostafa

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
303 KB
Volume
36
Category
Article
ISSN
0233-111X

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✦ Synopsis

Twelve isolates of zoosporic fungi belonging to four species (three isolates each) of the genus Suprolegniu were tested for progesterone biotransformation. The three isolates tested of each of S. hypogynu and S. purusificu have the capacity to perform oxidative splitting of the side chain of progesterone with the formation of A4 androstene-3,17 dione, testosterone and testololactone. All the isolates tested of S. diclinu and S. furcutu failed to transform progesterone molecule into another steroid derivative. The chromatographic resolution of the mixture products obtained when S. hypogynu (isolate No. 1008-2) had acted on one gram progesterone revealed the presence of 15% unchanged progesterone, 25% A4-androstene-3, 17dione, 25% testosterone and 35% testololactone.

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