Transformation reactions of progesterone by different species of Streptomyces

✍ Scribed by F. M. Atta; Dr. A. A. Zohri

• Publisher: John Wiley and Sons
• Year: 1995
• Tongue: English
• Weight: 346 KB
• Volume: 35
• Category: Article
• ISSN: 0233-111X
• DOI: 10.1002/jobm.3620350102

✦ Synopsis

A systematic study of transformation reactions of the genus Streptomyces with respect to the progesterone molecule was undertaken. The types of transformation reactions by different Streptomyces species were evaluated from the point of view of taxonomy. The isolates tested were divided according to the transformation types into six groups: (1) a group of species transform progesterone to 16a-hydroxyprogesterone; (2) a group of species transform progesterone to 6p-hydroxyprogesterone;

(3) a group of species transform progesterone to 6p,1 la-dihydroxyprogesterone; (4) a group of species dehydrogenate progesterone in C1-* position; ( 5 ) a group of species transform progesterone to 3 derivatives namely 6p-hydroxyprogesterone, 6p,1 la-dihydroxyprogesterone and dehydrogenation in position C, -2 ; (6) a group of species with no capacity to transform progesterone into another steroid derivative. From the point of view of Streptomyces classification, the transformation reaction of progesterone fulfil all the requirements of taxonomic feature of Streptomyces. These appear to be specific properties and common to all the strains of individual Streptomyces species tested.