## Abstract For Abstract see ChemInform Abstract in Full Text.
Microbiological synthesis of 5-ethyl- and (E)-5-(2-bromovinyl)-2′-deoxyuridine
✍ Scribed by E. N. Kalinichenko; V. N. Barai; S. B. Bokut; V. V. Romanova; A. I. Zinchenko; G. Herrmann; I. A. Mikhailopulo
- Publisher
- Springer Netherlands
- Year
- 1989
- Tongue
- English
- Weight
- 301 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0141-5492
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E)-5-(2-bromovinyl)-2 0 -deoxyuridine (BVDU, Brivudin, Zostex 1 , Zerpex 1 , Zonavir 1 ), now more than 20 years after its discovery, still stands out as a highly potent and selective inhibitor of herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) infections. It has been used in th
A series of forty 5'-ester derivatives of 5-ethyl-2'-deoxyuridine (EDU) have been evaluated for their inhibitory effects on the growth and metabolism of routine leukemia L1210 cells. Several EDU esters proved as potent as EDU in their inhibitory effects on L1210 cell growth (inhibitory dose-50: 5-10