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Microbiological conversion of 19-nortestosterone: (IV) 15α-hydroxylation

✍ Scribed by J. de Flines; W. F. van der Waard; W. J. Mijs; S. A. Szpilfogel

Book ID
104586580
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
266 KB
Volume
82
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

Microbiological reaction of 19‐nortestosterone with Penicillium sp.ATCC 11598 leading to about equal amounts of the 15α‐hydroxy‐derivative and 15α‐hydroxy‐19‐nor‐androst‐4‐one‐3,17‐dione is described. Fermentation of 19‐nortestosterone with Fusarium orthoceras afforded mainly 15α‐hydroxy‐19‐norandrost‐4‐ene‐3,17‐dione and only minor amounts of 15α‐hydroxy‐19‐nortestosterone.

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