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Microbiological conversion of 19-nortestosterone: (II) 10- and 11-hydroxylation

✍ Scribed by J. de Flines; W. F. van der Waard; W. J. Mijs; S. A. Szpilfogel

Book ID
104586578
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
468 KB
Volume
82
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

Fermentation of 19‐nortestosterone with Curvularia lunata or with Botrytis paeoniae yielded mainly the 10β‐hydroxy‐derivative. Fermentation with Aspergillus ochraceus afforded the 11α‐hydroxy‐derivative in good yield.

10β‐Hydroxy‐19‐nortestosterone with Corynebacterium simplex yielded 10β, 17β‐dihydroxy‐19‐norandrosta‐1,4‐dien‐3‐one.

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