Microbial transformation of 17α-cyanomethyl-17-hydroxy-4,9-estradien-3-one (STS 557) and 17α-cyanomethyl-19-nortestosterone by Mycobacterium smegmatis
✍ Scribed by G. Hobe; R. Schön; C. Hörhold; M. Hübner; W. Schade; K. Schubert
- Book ID
- 118978934
- Publisher
- Elsevier Science
- Year
- 1982
- Tongue
- English
- Weight
- 659 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0039-128X
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📜 SIMILAR VOLUMES
## Abstract An improved synthesis of the tritium labelled form of the new pharmacon DIENOGEST is described. The [^14^α,15α‐^3^‐H]DIENOGEST was obtained with a specific activity of 51 Ci/mmol and a radiochemical purity > 98%.
## Abstract The preparation of [14α,15α‐^3^H]‐17α‐cyanomethyl‐17ß‐hydroxy‐estra‐4,9‐diene‐3‐one (X) starting with catalytic tritiation of 3‐methoxy‐estra‐1,3,5(10),8,14‐pentaene‐17ß‐ol (I) and followed by a ten‐step synthesis is described. This new high effective gestagene STS 557 was obtained with