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Microbial oxidation in synthesis: Preparation of 6-deoxy cyclitol analogues of myo-inositol 1,4,5-trisphosphate from benzene

✍ Scribed by Steven V. Ley; Margarita Parra; Alison J. Redgrave; Francine Sternfeld; Angel Vidal


Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
261 KB
Volume
30
Category
Article
ISSN
0040-4039

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myo-Inositol 1,4,6-u-&phosphate, in optically inactive and active forms, was prepared in order to compare its biological activity with that of myo-inositol 1,3,4,6-tetrakisphosphate which releases Ca2+ from an intracellular store.

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The synthesis of 6-deoxy-D-myo-inositol-l,3,4,5-tetrakisphosphates is described. The access to opticaly pure Ins(l,3,4,5)P4 analogues was carried out from deoxy myo inositol precursors derived from D-galactose. Modification of Ins(1,3,4,5)P4 analogues by lipophilie substituents has been investigated