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Stereoselective synthesis of myo-inositol-1,3,4,5-tetrakisphosphate analogues from 6-deoxy d-inositol precursors

✍ Scribed by Didier Dubreuil; Jeannine Cleophax; Mauro Vieira de Almeida; C. Verre-Sebrié; Muriel Pipelier; Georges Vass; Stéphane D. Gero

Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
631 KB
Volume
55
Category
Article
ISSN
0040-4020

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✦ Synopsis

The synthesis of 6-deoxy-D-myo-inositol-l,3,4,5-tetrakisphosphates is described. The access to opticaly pure Ins(l,3,4,5)P4 analogues was carried out from deoxy myo inositol precursors derived from D-galactose. Modification of Ins(1,3,4,5)P4 analogues by lipophilie substituents has been investigated in order to produce neutral phosphate derivatives aimed to be incorporated in cell membrane for in vivo evaluation.

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