Michael addition of amines to vinyl sulfonamides on solid support

✍ Scribed by Gergely M Makara; Yao Ma

• Book ID: 104230758
• Publisher: Elsevier Science
• Year: 2001
• Tongue: French
• Weight: 81 KB
• Volume: 42
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)00692-x

✦ Synopsis

A solid phase synthesis for Michael addition of amines to vinylsulfonamides has been developed. The method enables synthesis of b-aminosulfonamides with high yields and purity. Further functionalization of adducts derived from primary amines is demonstrated.