MGr1-Ag is associated with multidrug-resistant phenotype of gastric cancer cells
β Scribed by Yongquan Shi; Ying Han; Xin Wang; Yanqiu Zhao; Xiaoxuan Ning; Bing Xiao; Daiming Fan
- Publisher
- Springer
- Year
- 2002
- Tongue
- English
- Weight
- 570 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1436-3291
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π SIMILAR VOLUMES
Resistance to chemotherapy is intrinsically present in most nonsmall-cell lung carcinomas (NSCLC). No parameter has yet been determined to predict the response to chemotherapy. However, MRP1 (multidrug resistance-associated protein) is suspected to play an important role in resistance to treatment.
Multidrug resistance (MDR) in human cancer cells is multifactorial. Previously, we reported on the association between expression of P-glycoprotein (Pgp), the multidrug resistanceassociated protein (MRP), and the lung resistance protein (LRP) with the MDR phenotype in the NCI panel of 60 human cance