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Impaired expression of hepatic multidrug resistance protein 2 is associated with posthepatectomy hyperbilirubinemia in patients with biliary cancer

✍ Scribed by Tatsuharu Yamada; Toshiyuki Arai; Masato Nagino; Koji Oda; Junichi Shoda; Hiroshi Suzuki; Yuichi Sugiyama; Yuji Nimura

Publisher
Springer
Year
2005
Tongue
English
Weight
254 KB
Volume
390
Category
Article
ISSN
1435-2451

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## Abstract Hepatitis B Γ— antigen, or HBxAg, contributes importantly to the pathogenesis of hepatocellular carcinoma (HCC). Given that HBxAg constitutively activates β‐catenin and that upregulated ErbB‐2 promotes β‐catenin signaling in other tumor types, experiments were designed to ask whether HBx