A specific CpG methylation pattern of th
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Klaus K.-F. Herfarth; Thomas P. Brent; Rebecca P. Danam; Joanna S. Remack; Ira J
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Article
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1999
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John Wiley and Sons
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English
β 122 KB
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The enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) protects cells from the cytotoxic and mutagenic effects of alkylating agents. Approximately 20% of tumor cell lines lack MGMT activity and are highly sensitive to alkylating agents. In established cancer cell lines, MGMT expression appears t