Hypermethylation of MGMT and DAPK gene promoters is associated with tumorigenesis and metastasis in oral squamous cell carcinoma
โ Scribed by Yong-Kie Wong; Li-Tsu Lee; Chung-Ji Liu
- Book ID
- 119293962
- Publisher
- Elsevier
- Year
- 2011
- Tongue
- English
- Weight
- 306 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1991-7902
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## Abstract Aberrant promoter hypermethylation of tumorโassociated genes leading to their inactivation is a common event in many cancer types. Using a sensitive restrictionโmultiplex PCR method, we studied the promoter hypermethylation profile of the __p16, p15, hMLH1, MGMT__ and __Eโcad__ genes in
Aberrant methylation of CpG islands within promoter regions is associated with transcriptional inactivation of various tumor suppressor genes in neoplasms. Recently, O 6 -methylguanine-DNA methyltransferase, MGMT, was shown to be hypermethylated in certain carcinomas, resulting in loss of MGMT prote