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Promoter hypermethylation of CDKN2A , MGMT , MLH1 , and DAPK genes in laryngeal squamous cell carcinoma and their associations with clinical profiles of the patients

✍ Scribed by Pierini, Stefano; Jordanov, Stanislav H.; Mitkova, Atanaska V.; Chalakov, Ivan J.; Melnicharov, Mincho B.; Kunev, Kuncho V.; Mitev, Vanio I.; Kaneva, Radka P.; Goranova, Teodora E.


Book ID
120532418
Publisher
John Wiley and Sons
Year
2013
Tongue
English
Weight
549 KB
Volume
36
Category
Article
ISSN
1043-3074

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## Abstract Aberrant promoter hypermethylation of tumor‐associated genes leading to their inactivation is a common event in many cancer types. Using a sensitive restriction‐multiplex PCR method, we studied the promoter hypermethylation profile of the __p16, p15, hMLH1, MGMT__ and __E‐cad__ genes in