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Metronidazole photodegradation in aqueous solution by using photosensitizers and hydrogen peroxide

✍ Scribed by Manuel Sánchez-Polo; José Rivera-Utrilla; Gonzalo Prados-Joya; Raúl Ocampo-Pérez

Publisher
Wiley (John Wiley & Sons)
Year
2012
Tongue
English
Weight
165 KB
Volume
87
Category
Article
ISSN
0268-2575

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✦ Synopsis

Abstract

BACKGROUND: The effectiveness of UV radiation on the indirect photodegradation of metronidazole (MNZ) conducting a kinetic study of the process in the presence of radical promoter (H~2~O~2~) and photosensitizer (Sens) promoters (duroquinone, tetrahydroxyquinone, tetrachloro‐1,4‐benzoquinone, 4‐carboxy‐benzophenone, 2,4‐dihydroxybenzophenone, 4‐hydroxybenzophenone, and 4,4′‐dihydroxybenzophenone) was investigated.

RESULTS: The electron‐donating groups of photosensitizers may favor MNZ photodegradation through electron transfer. However, the photosensitizers studied showed low effectiveness of MNZ photodegradation in aqueous phase. The presence of H~2~O~2~ substantially increased MNZ photodegradation rate, which was enhanced by increasing the concentration of hydrogen peroxide in the system. The contribution of direct photolysis of MNZ in the UV/H~2~O~2~ system was drastically decreased with increasing H~2~O~2~ concentrations.

CONCLUSIONS: The low effectiveness obtained with most of the Sens used demonstrates that metronidazole cannot be photoxidized by indirect photooxidation in aqueous solution. Copyright © 2012 Society of Chemical Industry

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