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Methyltransferase Recruitment and DNA Hypermethylation of Target Promoters by an Oncogenic Transcription Factor

✍ Scribed by Di Croce, L.

Book ID: 118185094
Publisher: American Association for the Advancement of Science
Year: 2002
Tongue: English
Weight: 535 KB
Volume: 295
Category: Article
ISSN: 0036-8075
DOI: 10.1126/science.1065173

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## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)