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Loss expression of O6-methylguanine DNA methyltransferase by promoter hypermethylation and its relationship to betel quid chewing in oral squamous cell carcinoma

✍ Scribed by Sung-Hsien Huang; Herng-Sheng Lee; Kwei Mar; Dar-Der Ji; Mao-Suan Huang; Kan-Tai Hsia

Book ID: 116942821
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 724 KB
Volume: 109
Category: Article
ISSN: 1528-395X
DOI: 10.1016/j.tripleo.2009.12.019

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## Abstract O^6^‐methylguanine‐DNA methyltransferase (MGMT) is a repair protein that specifically removes promutagenic alkyl groups from the O^6^ position of guanine in DNA. __MGMT__ is transcriptionally silenced by promoter hypermethylation in several human cancers. Methylation‐specific PCR (MSP)