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Dual Regulation of the Met4 Transcription Factor by Ubiquitin-Dependent Degradation and Inhibition of Promoter Recruitment

โœ Scribed by Laurent Kuras; Astrid Rouillon; Traci Lee; Regine Barbey; Mike Tyers; Dominique Thomas


Book ID
117736841
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
739 KB
Volume
10
Category
Article
ISSN
1097-2765

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Overexpression of the HER2/Neu receptor is correlated to a poor prognosis in tumor patients and leads to stimulation of mitogen-activated protein kinase (MAPK) signaling pathways, which in turn activate transcription factors, such as the ETS protein ER81. Here, we have analyzed whether, on the other