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Methyl­felbamate

✍ Scribed by Hempel, Andrew ;Camerman, Norman ;Mastropaolo, Donald ;Camerman, Arthur

Publisher
International Union of Crystallography
Year
2005
Tongue
English
Weight
225 KB
Volume
61
Category
Article
ISSN
1600-5368

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✦ Synopsis

The crystal structure of 2-methyl-2-phenyl-1,3-propanediol dicarbamate (methylfelbamate), C 12 H 16 N 2 O 4 , contains two independent molecules in the asymmetric unit. The hydrogenbonding scheme is three-dimensional and involves interactions of the type N-HÁ Á ÁO, C-HÁ Á ÁO and N-HÁ Á Á(arene). Stereochemical and molecular modelling investigations indicate that the mechanism for anti-epileptic action of the compound is probably different from those of other anticonvulsants.

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## USA A synthesis of felbamate-d, (2-phenyl-1,3-propanediol-l,l,3,3-d, dicarbamate) starting from diethyl phenylmalonic acid ester and lithium aluminum deuteride was developed. material to felbamate-d, via the intermediate, 2-phenyl-1,3-propanediol- 1,1,3,3-d,. The final overall yield was 44%. T