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Methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and FOLFOX response in colorectal cancer patients

✍ Scribed by Marie-Christine Etienne-Grimaldi; Gérard Milano; Frédérique Maindrault-Gœbel; Benoist Chibaudel; Jean-Louis Formento; Mireille Francoual; Gérard Lledo; Thierry André; May Mabro; Laurent Mineur; Michel Flesch; Elisabeth Carola; Aimery De Gramont


Book ID
108642423
Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
728 KB
Volume
69
Category
Article
ISSN
0306-5251

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## Communicated by Mark Paalman Severe deficiency of methylenetetrahydrofolate reductase (MTHFR) is the most common inborn error of folate metabolism. Patients are characterized by severe hyperhomocysteinemia, homocystinuria and a variety of neurological and vascular problems. Eighteen rare mutatio