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Dihydrofolate reductase (DHRF) 19-bp intron-1 deletion and methylenetetrahydrofolate reductase (MTHFR) C677T polymorphisms in breast cancer

✍ Scribed by Ragip Çam; Aydan Eroglu; Yonca Egin; Nejat Akar

Publisher: Springer US
Year: 2008
Tongue: English
Weight: 132 KB
Volume: 115
Category: Article
ISSN: 0167-6806
DOI: 10.1007/s10549-008-0054-x

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## Abstract Periconceptional maternal folic acid supplementation can prevent up to 70% of pregnancies affected with neural tube defects (NTDs), including spina bifida. This has focused attention on folate‐related genes such as dihydrofolate reductase (__DHFR__) in a bid to identify the genetic fact