New 19 bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR): A risk factor for spina bifida acting in mothers during pregnancy?

The 19-bp deletion polymorphism in intro

The 19-bp deletion polymorphism in intron-1 of dihydrofolate reductase (DHFR) may decrease rather than increase risk for spina bifida in the Irish population

✍ Anne Parle-McDermott; Faith Pangilinan; James L. Mills; Peadar N. Kirke; Eileen 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 133 KB

## Abstract Periconceptional maternal folic acid supplementation can prevent up to 70% of pregnancies affected with neural tube defects (NTDs), including spina bifida. This has focused attention on folate‐related genes such as dihydrofolate reductase (__DHFR__) in a bid to identify the genetic fact