Methylation status of SOCS1 and SOCS3 in BCR-ABL negative and JAK2V617F negative chronic myeloproliferative neoplasms
✍ Scribed by Marta Fernández-Mercado; Virginia Cebrián; Begoña Euba; Marta García-Granero; María J. Calasanz; Francisco J. Novo; José L. Vizmanos; Marina García-Delgado
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 73 KB
- Volume
- 32
- Category
- Article
- ISSN
- 0145-2126
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## Abstract Chromosomal deletions of band 13q14 occur recurrently in __BCR/ABL__ negative chronic myeloproliferative disorders (CMPD), including myelosclerosis with myeloid metaplasia (MMM), polycythemia vera (PV), essential thrombocythemia (ET), juvenile chronic myeloid leukemia (JCML), and the so
## Abstract ## BACKGROUND. Interferon‐alpha (IFN‐α) has shown significant activity in the treatment of BCR‐ABL–negative myeloproliferative disorders (MPDs), particularly essential thrombocythemia (ET) and polycythemia vera (PV). PEG‐IFN‐α‐2b is a pegylated IFN‐α‐2b with a significant advantage ove
## Abstract This report describes a chronic myelogenous leukaemia patient with an apparently normal bone marrow karyotype but __BCR/ABL__ fusion‐gene‐positive. Commercial FISH probes showed an atypical pattern and the __BCR/ABL__ fusion transcript was detected by RT‐PCR, but not the reciprocal __AB