Methylation profiles of sporadic colorectal cancer and adenoma
β Scribed by Bai, Alfa H.C.; Tong, Joanna H.M.; Man, Ellen P.S.; Chan, Michael W.Y.; To, Ka-Fai; Sung, Joseph J.Y.; Leung, Wai K.
- Book ID
- 123385300
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- English
- Weight
- 181 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Colorectal adenomas have traditionally been regarded as homogeneous. The aim of our study was to identify molecular features that may differentiate sporadic adenomas from familial adenomas such as Familial Adenomatous Polyposis (FAP) and Multiple Adenoma patients. DNA methylation was te
## Abstract Aberrant DNA methylation, microsatellite instability (MSI) and chromosomal instability (CIN) are wellβcharacterised molecular features of sporadic colorectal cancers (CRCs). In addition to CpG island methylator phenotype (CIMP) associated with MSI, an intermediate methylation subgroup i