CpG island methylation as an early event during adenoma progression in carcinogenesis of sporadic colorectal cancer

CpG island methylation of genes accumula

CpG island methylation of genes accumulates during the adenoma progression step of the multistep pathogenesis of colorectal cancer

✍ Young-Ho Kim; Zsolt Petko; Slavomir Dzieciatkowski; Li Lin; Mahan Ghiassi; Steve 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 330 KB

## Abstract Genetic alterations occur during the adenoma‐carcinoma sequence of colon cancer formation and drive the initiation and progression of colon cancer formation. The aberrant methylation of genes is an alternate, epigenetic mechanism for silencing tumor suppressor genes in colon cancer. The