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Methylation profile of genes CDKN2A (p14 and p16), DAPK1, CDH1, and ADAM23 in head and neck cancer

✍ Scribed by Marilia F. Calmon; Jucimara Colombo; Fabrício Carvalho; Fátima P. Souza; José F.G. Filho; Érica E. Fukuyama; Anamaria A. Camargo; Otávia L.S. Caballero; Eloíza H. Tajara; José A. Cordeiro; Paula Rahal


Book ID
113513043
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
227 KB
Volume
173
Category
Article
ISSN
0165-4608

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The tumor suppressor gene CDKN2 (p16/MTS1) resides on chromosome 9p21 and encodes a 16 kDa inhibitor of the cyclin-dependent kinases. Inactivation of CDKN2 by homozygous deletion, point mutation, and recently described aberrant methylation in the 5' promoter region may increase progression through t