Promoter methylation and loss of p16INK4a gene expression in head and neck cancer
✍ Scribed by Semra Demokan; Alice Chuang; Yusufhan Suoğlu; Murat Ulusan; Zubeyde Yalnız; Joseph A. Califano; Nejat Dalay
- Book ID
- 112097617
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 350 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1043-3074
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## Abstract The potential role of __p16__^__INK4a__^ methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of __p16__^__INK4a__^ by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it i
## Abstract Inactivation of the __p16^INK4A^__ (__CDKN2A)__ gene in the Rb pathway is among the most common somatic alterations observed in tobacco‐related solid tumors, including head and neck squamous cell carcinoma (HNSCC). In addition, a low folate diet is an important risk factor for HNSCC. De