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Methylation of theKEAP1gene promoter region in human colorectal cancer

✍ Scribed by Naoyuki Hanada; Takenori Takahata; Qiliang Zhou; Xulu Ye; Ruowen Sun; Jugoh Itoh; Atsushi Ishiguro; Hiroshi Kijima; Junsei Mimura; Ken Itoh; Shinsaku Fukuda; Yasuo Saijo


Book ID
115010452
Publisher
BioMed Central
Year
2012
Tongue
English
Weight
1000 KB
Volume
12
Category
Article
ISSN
1471-2407

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## Abstract The __FES__ locus encodes a unique nonreceptor protein‐tyrosine kinase (FES) traditionally viewed as a proto‐oncogene but more recently implicated as a tumor suppressor in colorectal cancer (CRC). Recent studies have demonstrated that while FES is expressed in normal colonic epithelium,