Microsatellite instability (MSI), which is recognized as an important mechanism in tumorigenesis, has been reported in familial gastric cancers (FGC). However, genetic defects responsible for this phenotype, that is, mutations in mismatchrepair genes such as hMLH1 and hMSH2, have not been detected i
Methylation of hMLH1 promoter correlates with the gene silencing with a region-specific manner in colorectal cancer
β Scribed by Deng, G; Peng, E; Gum, J; Terdiman, J; Sleisenger, M; Kim, Y S
- Book ID
- 109997161
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 192 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0007-0920
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Nonrandom, widespread promoter methylation of tumor suppressor genes is a common mechanism of gene inactivation during tumorigenesis. We examined the methylation status of two distinct regions of the __MLH1__ promoter (proximal and distal to the transcription start site) and the __MLH1_
The enzyme O 6 -methylguanine-DNA methyltransferase (MGMT) protects cells from the cytotoxic and mutagenic effects of alkylating agents. Approximately 20% of tumor cell lines lack MGMT activity and are highly sensitive to alkylating agents. In established cancer cell lines, MGMT expression appears t
## Abstract Promoterβregion DNA methylation inhibits transcription. A twoβstage SENCAR (__sen__sitive to mouse __car__cinogenesis) mouse skin carcinogenicity model was used to examine geneβspecific changes in methylation during skin tumor promotion. Analysis was performed on 7,12βdimethylbenz[a]ant