Methylation and QTDT analysis of the 5-HT2A receptor 102C allele: Analysis of suicidality in major psychosis
โ Scribed by Vincenzo De Luca; Emanuela Viggiano; Ranbir Dhoot; James L. Kennedy; Albert H.C. Wong
- Book ID
- 113750441
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 177 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0022-3956
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## Abstract The serotonin 2A (__5โHT2A__) receptor gene has been implicated in the pathogenesis of suicidal behavior by a genetic association between the 5โHT2A C102T silent polymorphism and suicidality in patients with major depression. However, a recent metaโanalysis failed to confirm this associ
We selected 42 patients with bipolar disorder type I (BPI) and 40 healthy controls for genetic analysis of DNA polymorphisms in the serotonin receptor 2c (5-HTR2c) and serotonin transporter (5-HTT) genes. No significant associations were found in the total patient sample. However, when the individua