Mass spectrometric quantification of asp
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Susan E. Abbatiello; Yuan-Xiang Pan; Mi Zhou; Alan S. Wayne; Timothy D. Veenstra
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Article
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2008
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Elsevier
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English
β 542 KB
The appearance of asparaginase-resistant acute lymphoblastic leukemia (ALL) in transformed cell lines has been correlated with increased expression of asparagine synthetase (ASNS). Recent measurements using mRNA-based assays have raised doubts, however, as to the importance of ASNS protein in the ce