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Methylation analysis of asparagine synthetase gene in acute lymphoblastic leukemia cells

✍ Scribed by Akagi, T; Yin, D; Kawamata, N; Bartram, C R; Hofmann, W-K; Wolf, I; Miller, C W; Koeffler, H P


Book ID
110056735
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
161 KB
Volume
20
Category
Article
ISSN
0887-6924

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The appearance of asparaginase-resistant acute lymphoblastic leukemia (ALL) in transformed cell lines has been correlated with increased expression of asparagine synthetase (ASNS). Recent measurements using mRNA-based assays have raised doubts, however, as to the importance of ASNS protein in the ce