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Methotrexate-resistant mechanisms in human choriocarcinoma cells

โœ Scribed by Kei-ichiro Sakai; Norio Wake; Takafumi Fujino; Teruko Yasuda; Hidenori Kato; Sei-ichiro Fujimoto; Kei Fujinaga


Book ID
119053103
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
710 KB
Volume
34
Category
Article
ISSN
0090-8258

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Methotrexate-induced resistance to dacti
โœ Setsuko Goto; Yoshie Okayama; Bachelor Of Agriculture; Chen Fan; Shiomi Ueda; Ba ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 458 KB

NaUCC-2, a choriocarcinoma cell line, was derived from a patient who had a very poor clinical response to combination chemotherapy. Methotrexate (MTX) might have inhibited the antitumor effect of dactinomycin. To investigate this point, in vitro studies were performed to determine the sensitivity an