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Mechanisms of decreased drug transport in cells resistant to methotrexate and cisplatinum

✍ Scribed by Urbano, A.Godofredo; Wong, Yuk Chor; Kakefuda, Mika; Bernal, Samuel D.


Book ID
122405782
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
158 KB
Volume
6
Category
Article
ISSN
0169-5002

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A cell line derived from H35 hepatoma cells resistant to methotrexate (MTX) as a result of a defective transport systern for M T X has been examined to determine how closely the variant resembles the parent cells with regard to other cells to catalyze the poly-y-glutamylation of M T X was approxdenc