Methotrexate enhances prostaglandin -stimulated heat shock protein 27 induction in osteoblasts
โ Scribed by Minoru Yoshida; Masayuki Niwa; Akira Ishisaki; Kouseki Hirade; Hidenori Ito; Katsuji Shimizu; Kanefusa Kato; Osamu Kozawa
- Book ID
- 116838312
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 400 KB
- Volume
- 71
- Category
- Article
- ISSN
- 0952-3278
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It is generally recognized that osteoporosis is a common complication of patients with glucocorticoid excess and that glucocorticoid receptor is associated with heat shock protein (HSP) 70 and HSP90 in a heterocomplex. In the present study, we investigated whether glucocorticoid induces HSP27, HSP70