Mechanism of prostaglandin D2-stimulated heat shock protein 27 induction in osteoblasts
โ Scribed by Osamu Kozawa; Takanobu Otsuka; Daijiro Hatakeyama; Masayuki Niwa; Hiroyuki Matsuno; Hidenori Ito; Kanefusa Kato; Nobuo Matsui; Toshihiko Uematsu
- Book ID
- 114283587
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- English
- Weight
- 188 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0898-6568
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We previously reported that prostaglandin F 2โฃ (PGF 2โฃ ) activates both phosphoinositide-hydrolyzing phospholipase C and phosphatidylcholine-hydrolyzing phospholipase D in osteoblast-like MC3T3-E1 cells and then induces the activation of protein kinase C (PKC). In this study, we investigated the eff
It is generally recognized that osteoporosis is a common complication of patients with glucocorticoid excess and that glucocorticoid receptor is associated with heat shock protein (HSP) 70 and HSP90 in a heterocomplex. In the present study, we investigated whether glucocorticoid induces HSP27, HSP70