Inhibition of Heat Shock Induction of Heat Shock Protein 70 and Enhancement of Heat Shock Protein 27 Phosphorylation by Quercetin Derivatives
โ Scribed by Wang, Rongsheng E.; Kao, Jeffrey L.-F.; Hilliard, Carolyn A.; Pandita, Raj K.; Roti Roti, Joseph L.; Hunt, Clayton R.; Taylor, John-Stephen
- Book ID
- 120355348
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 537 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0022-2623
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Constitutive expression of human hsp27 resulted in a 100-fold increase in survival to a single lethal heat shock in CHO cells without effecting the development of thermotolerance. A possible mechanism for the thermoprotective function of hsp27 may be increased recovery of protein synthesis and RNA s
Animal experiments have shown that members of the heat shock protein (HSP) family have cytoprotective properties against ischaemia. In experimentally induced cardiac ischaemia, the induction of HSP70s correlates with reduced infarct size and enhanced myocardial function and endothelial recovery. Dir