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Method for Stabilizing Protein−Ligand Complexes in Nanoelectrospray Ionization Mass Spectrometry

✍ Scribed by Sun, Jiangxiao; Kitova, Elena N.; Klassen, John S.

Book ID
126013228
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
211 KB
Volume
79
Category
Article
ISSN
0003-2700

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## Abstract We describe an approach for the determination of binding constants for protein–ligand complexes with electrospray ionization mass spectrometry, based on the observation of unbound ligands competing for binding to a protein target. For the first time, dissociation constants lower than pi