✦ LIBER ✦

Method for estimating rate constants for absorption, metabolism, and elimination from urinary excretion data

✍ Scribed by John G. Wagner

Publisher: John Wiley and Sons
Year: 1967
Tongue: English
Weight: 504 KB
Volume: 56
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600560413

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Estimation of rate constants for absorpt

Estimation of rate constants for absorption and elimination from blood concentration data

✍ John G. Wagner; Carl M. Metzler 📂 Article 📅 1967 🏛 John Wiley and Sons 🌐 English ⚖ 166 KB

Evaluation of methods for estimating the

Evaluation of methods for estimating the rate constant of a one-compartment absorption model when absorption and elimination rate constants are equal

✍ John F. Hoke; William R. Ravis 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 223 KB 👁 1 views

Data are mean predicted k values. Conditions: (A) nine data sets, 10% random error; (6) six data sets, 20% random error; (C) nine data sets, limited Cand t,10% random error. The real value of k for conditions A-C is 0.5. Values in parentheses are coefficients of variation; ranges are ranges of predi

Constrained least squares methods for es

Constrained least squares methods for estimating reaction rate constants from spectroscopic data

✍ Sabina Bijlsma; Hans F. M. Boelens; Huub C. J. Hoefsloot; Age K. Smilde 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 250 KB

A method for estimating catechol estroge

A method for estimating catechol estrogen metabolism from excretion of noncatechol estrogens

✍ H. M. Lemon; J. W. Heidel; J. F. Rodriguez-Sierra 📂 Article 📅 1991 🏛 John Wiley and Sons 🌐 English ⚖ 604 KB

The relationship of catechol estrogen metabolism to disease has seldom been investigated because of analytic difficulties. Estradiol (E2) and estrone (El) are oxidized simultaneously at either ring A or ring D, and the rate of catechol estrogen formation (rz) is reciprocally related to the rate of 1

A statistical method for the determinati

A statistical method for the determination of absorption rate constant estimated using the rat single pass intestinal perfusion model and multiple linear regression

✍ Steven C. Sutton; M. T. S. Rinaldi; J. M. McCarthy; K. E. Vukovinsky 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 1 views

The guide "Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate Release Solid Dosage Forms Containing Certain Active Moieties/Active Ingredients Based on a Biopharmaceutical Classification System" (Rockville, MD: CDER, 2000) outlined non-in vivo tests of permeability that may s

A convenient method for estimating the q

A convenient method for estimating the quantity of drug eliminated by the routes other than hepatic metabolism and renal excretion and the fraction of drug that reaches the “first pass” after oral administration

✍ Leonid M. Berezhkovskiy 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 1 views

The comparison of routine pharmacokinetic data obtained after intravenous and oral drug administration allows to figure out that some quantity of drug, which reached the systemic circulation, was eliminated from the body by routes other than hepatic metabolism and renal excretion. This quantity is e