Metformin in the treatment of non-alcoholic steatohepatitis: a pilot open label trial
β Scribed by S. Nair; A. M. Diehl; M. Wiseman; G. H. Farr Jr; R. P. Perrillo
- Book ID
- 108603647
- Publisher
- John Wiley and Sons
- Year
- 2004
- Tongue
- English
- Weight
- 82 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0269-2813
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## Summary **Background** :βIncreased insulin resistance is the major pathogenic mechanism in the development of nonβalcoholic steatohepatitis. **Aim** :βTo investigate the therapeutic effect of metformin, a wellβknown insulinβsensitizing agent, in the treatment of nonβalcoholic steatohepatitis.
Medication combinations that improve the efficacy of thiazolidinediones or ameliorate weight-gain side effects of therapy represent an attractive potential treatment for (NASH). The aim of this randomized, open-label trial was to assess the efficacy of rosiglitazone and metformin in combination vers