Clinical trial: pilot study of metformin for the treatment of non-alcoholic steatohepatitis
β Scribed by R. LOOMBA; G. LUTCHMAN; D. E. KLEINER; M. RICKS; J. J. FELD; B. B. BORG; A. MODI; P. NAGABHYRU; A. E. SUMNER; T. J. LIANG; J. H. HOOFNAGLE
- Book ID
- 108605495
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 238 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0269-2813
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## Summary **Background** :βIncreased insulin resistance is the major pathogenic mechanism in the development of nonβalcoholic steatohepatitis. **Aim** :βTo investigate the therapeutic effect of metformin, a wellβknown insulinβsensitizing agent, in the treatment of nonβalcoholic steatohepatitis.
Non-alcohol-induced steatohepatitis (NASH) is characterized by elevated serum aminotransferase activities with hepatic steatosis, inflammation, and occasionally fibrosis that may progress to cirrhosis. No established treatment exists for this potentially serious disorder. Our aim was to conduct a pi