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Metal−Substrate Interactions Facilitate the Catalytic Activity of the Bacterial Phosphotriesterase †

✍ Scribed by Hong, Suk-Bong; Raushel, Frank M.


Book ID
127227571
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
770 KB
Volume
35
Category
Article
ISSN
0006-2960

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Phosphotriesterase (PTE) is a zinc metalloenzyme that catalyzes the hydrolysis of an extensive array of organophosphate pesticides and mammalian acetylcholinesterase nerve agents. Although the three-dimensional crystal structure of PTE has been solved (M. M. Benning et al., Biochemistry 34:7973-7978