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Structure-activity relationships in the hydrolysis of substrates by the phosphotriesterase from Pseudomonas diminuta

โœ Scribed by Donarski, William J.; Dumas, David P.; Heitmeyer, David P.; Lewis, Vincent E.; Raushel, Frank M.


Book ID
126149120
Publisher
American Chemical Society
Year
1989
Tongue
English
Weight
643 KB
Volume
28
Category
Article
ISSN
0006-2960

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A structure-activity relationship is presented that satisfactorily predicts the rates of hydrolysis of a series of acetylglycine derivatives by porcine aminoacylase. It is apparent that the substrate specificity of aminoacylase is mainly kinetic in origin, the observed correlation with Taft's E s pa