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Metalation of diazines. VI. Metalation of pivaloylaminopyrazine and N-t-butylpyrazinamide. Unusual regioselectivity in the metalation reaction

✍ Scribed by A. Turck; N. Plé; D. Trohay; B. Ndzi; G. Quéguiner

Book ID
112130335
Publisher
Journal of Heterocyclic Chemistry
Year
1992
Tongue
English
Weight
260 KB
Volume
29
Category
Article
ISSN
0022-152X

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## Abstract The regioselectivity of the metalation of 2‐chloro‐6‐methoxypyrazine, 2‐fluoro‐6‐methoxypyrazine and 3‐fluoro‐6‐chloropyridazine was studied; the relative __ortho__‐directing power was F > OMe > Cl.